40 TV & Film Best Friends Who Hated Each Other in Real Life

#02 Blake Lively & Leighton Meester – Gossip Girl

On TV, Serena and Blair were the ultimate “fight today, friends tomorrow” duo. But Blake Lively and Leighton Meester didn’t have quite the same vibe off-camera. Rumors swirled that they didn’t click, and in 2010, Blake’s publicist admitted they weren’t close. It wasn’t a screaming-match kind of feud — more like polite distance. They worked together, smiled for the cameras, then went their separate ways once filming wrapped.